Matrix Metalloproteinase 3 Antibody / MMP3
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB) . MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA: 2-4 µg/mL for coating (order BSA/azide-free format)
UniProt
P08254
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 317-327 from the human protein were used as the immunogen for this Matrix Metalloproteinase 3 antibody.
Clonality
Monoclonal
Isotype
IgG1 λ
Clone
1B4
Applications
ELISA
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Matrix Metalloproteinase 3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Matrix Metalloproteinase 3 antibody is available for research use only.
Storage Conditions
Store the Matrix Metalloproteinase 3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Matrix Metalloproteinase 3 antibody should be determined by the researcher.
Image Legend
SDS-PAGE analysis of purified, BSA-free Matrix Metalloproteinase 3 antibody as confirmation of integrity and purity.
Documents
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
