TFB-TBOA

TFB-TBOA (CF3-Bza-TBOA) is a potent glutamate transporter blocker that potently suppresses the activity of glial transporters. TFB-TBOA shows IC50 values of 22, 17, and 300 nM for glutamate transporters EAAT1, EAAT2, and EAAT3 respectively in an uptake assay using cells transiently expressing EAATs[1].

Product Specifications

CAS Number

[480439-73-4]

Product Name Alternative

CF3-Bza-TBOA

UNSPSC

12352005

Target

EAAT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tfb-tboa.html

Purity

99.73

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(C=C1)C(F)(F)F)NC2=CC(CO[C@H](C(O)=O)[C@H](N)C(O)=O)=CC=C2

Molecular Formula

C19H17F3N2O6

Molecular Weight

426.34

References & Citations

[1]Shimamoto K, et al. Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters. Mol Pharmacol. 2004;65 (4) :1008-1015. |[2]Tsukada S, et al. Effects of a novel glutamate transporter blocker, (2S, 3S) -3-[3-[4- (trifluoromethyl) benzoylamino]benzyloxy]aspartate (TFB-TBOA), on activities of hippocampal neurons. Neuropharmacology. 2005;48 (4) :479-491. |[3]Bozzo L, et al. Inhibitory effects of (2S, 3S) -3-[3-[4- (trifluoromethyl) benzoylamino]benzyloxy]aspartate (TFB-TBOA) on the astrocytic sodium responses to glutamate. Brain Res. 2010;1316:27-34.