CD10 Antibody / Neprilysin
Recognizes a 100kDa glycoprotein, identified as CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA) . It is a cell surface enzyme with neutral metalloendopeptidase activity, which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, and on cells from patients with chronic myelocytic leukemia (CML) . It is also expressed on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/10^6 cells in 0.1ml, Western blot: 1-2 µg/mL, Immunofluorescence: 1-2 µg/mL
UniProt
P08473
Host
Mouse
Reactivity
Human
Immunogen
Full length human protein was used as the immunogen for the CD10 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
MME/1620
Applications
FACS, WB, IF
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the CD10 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD10 antibody is available for research use only.
Storage Conditions
Store the CD10 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CD10 antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
Image Legend
Immunofluorescent staining of human Ramos cells with CD10 antibody (clone MME/1620, green) and Reddot nuclear stain (red) .
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