LMO2 Antibody / Rhombotin 2
The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. It has a particular function in normal and lymphatic endothelial cells involving the regulation of angiogenesis and lymph-angiogenesis. Immunohistochemical studies have also demonstrated expression of LMO2 in both normal germinal center B-cells and germinal center-derived B-cell lymphomas, including follicular lymphoma and diffuse large B-cell lymphoma.The use of anti-LMO2 is valuable as a tool in the identification of lymphomas of B-cell origin. LMO2 is useful in differentiating follicular lymphoma (LMO2+) from nodal marginal zone lymphoma (LM02-) . It also is positive in Hodgkin s and Burkitt s lymphomas.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/10^6 cells in 0.1ml, Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P25791
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 23-140) was used as the immunogen for the LMO2 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
LMO2/1971
Applications
FACS, WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the LMO2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This LMO2 antibody is available for research use only.
Storage Conditions
Store the LMO2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the LMO2 antibody should be determined by the researcher.
Location
Nuclear, cytoplasmic
Image Legend
Western blot testing of human Ramos cell lysate with LMO2 antibody. Predicted molecular weight ~25 kDa.
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