Cytokeratin 13 Antibody / KRT13

Cytokeratin 13 (KRT13) is the major acidic keratin, which together with KRT4, its basic partner, is expressed in the suprabasal layers of non-cornified stratified epithelia including tongue mucosa, esophagus, anal canal epithelium, tracheal epithelium, uterine cervix, and urothelium. Defects in the KRT13 gene are a cause of white sponge nevus of cannon (WSN), a rare autosomal dominant disorder, which predominantly affects non-cornified stratified squamous epithelia and is characterized by the presence of soft, white and spongy plaques in the oral mucosa. KRT13 has been used as a marker for non-keratinized squamous epithelium. It is also expressed in various squamous metaplasia, but it is down regulated in squamous dysplasia and squamous carcinoma.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL, Flow cytometry: 1-2/million cells

UniProt

P13646

Host

Mouse

Reactivity

Human

Immunogen

A recombinant full-length human KRT13 protein was used as the immunogen for this Cytokeratin 13 antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

KRT13/2659

Applications

IF, IHC-P, FACS

Purity

Protein G affinity chromatography

Format

Purified

Buffer

1 mg/ml in 1X PBS; BSA free, sodium azide free

Reconstitution

Store the Cytokeratin 13 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This Cytokeratin 13 antibody is available for research use only.

Storage Conditions

Store the Cytokeratin 13 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Applications Notes

Optimal dilution of the Cytokeratin 13 antibody should be determined by the researcher.

Location

Cytoplasmic

Image Legend

Flow cytometry testing of permeabilized human HeLa cells with Cytokeratin 13 antibody (clone KRT13/2659) ; Red=isotype control, Blue= Cytokeratin 13 antibody.