Cytokeratin 4 Antibody / KRT4
Cytokeratin 4 (KRT4) is an intermediate filament protein associated with Cytokeratin 13 (KRT13) . It is expressed in suprabasal cells of non-keratinized stratified squamous epithelium of esophagus, cornea, anus, larynx, pharynx and tongue. Decreased expression of KRT4 is associated with head and neck squamous carcinoma. It is helpful in differentiation of squamous cell carcinoma of esophagus origin from that of thyroid origin.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells in 0.1ml, Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P19013
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 181-292) was used as the immunogen for this Cytokeratin 4 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
KRT4/2804
Applications
FACS, IF, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Cytokeratin 4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Cytokeratin 4 antibody is available for research use only.
Storage Conditions
Store the Cytokeratin 4 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Cytokeratin 4 antibody should be determined by the researcher.
Location
Cell membrane, cytoplasm, nucleus
Image Legend
Immunofluorescent staining of permeabilized human A549 cells with Cytokeratin 4 antibody (clone KRT4/2804, green) and Reddot nuclear stain (red) .
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