Cytokeratin 1 Antibody / CK1 / Keratin 1
Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8) . Keratins demonstrate tissue and differentiation specific expression profiles. Cytokeratin 1 is a hetero-tetramer of two type I as well as two type II keratins, keratin-10 (KRT10) . Keratin 1 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epithelia. Mutations in keratin 1 cause epidermolytic hyperkeratosis.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 0.1-0.2 µg/mL
UniProt
P04264
Host
Mouse
Reactivity
Human, Rat
Immunogen
Amino acids VRFVSTSYSGVTR from the C-terminal portion of the protein was used as the immunogen for this Cytokeratin 1 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
LHK1
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Cytokeratin 1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Cytokeratin 1 antibody is available for research use only.
Storage Conditions
Store the Cytokeratin 1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Cytokeratin 1 antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
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