Recombinant ITGB3 Antibody / Integrin beta 3 / CD61
Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain) . It associates with the V-chain (CD51) to form vitronectin receptor, or with the IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61) .The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P05106
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 385-490) was used as the immunogen for this ITGB3 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
RITGB3/2145
Type
Recombinant
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the recombinant ITGB3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant ITGB3 antibody is available for research use only.
Storage Conditions
Store the recombinant ITGB3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the recombinant ITGB3 antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
Image Legend
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