Myelin basic protein (4-14) (TFA)

Myelin basic protein 4-14 (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (Km=7 μM) . Myelin Basic Protein TFA is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca2+/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts[1][2].

Product Specifications

Product Name Alternative

MHP4-14 (TFA)

UNSPSC

12352209

Target

PKC

Type

Peptides

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/myelin-basic-protein-tfa.html

Purity

99.41

Solubility

H2O : ≥ 100 mg/mL

Smiles

O=C(C(F)(F)F)O.O=C([C@@H](N)CCC(N)=O)N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC2=CC=C(O)C=C2)=O)CCCCN)=O)CO)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CO)=O)CCC1)=O)CCCNC(N)=N)=O)CCCCN

Molecular Formula

C60H103N21O17·C2HF3O2

Molecular Weight

1504.61

References & Citations

[1]Farrar YJ, et al. A phosphatase resistant substrate for the assay of protein kinase C in crude tissue extracts. Biochem Biophys Res Commun. 1991;180 (2) :694-701. |[2]Yasuda I, et al. A synthetic peptide substrate for selective assay of protein kinase C. Biochem Biophys Res Commun. 1990;166 (3) :1220-1227.