Growth Hormone Antibody / GH1

Pituitary growth hormone (GH) plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Anti-GH is a useful marker in classification of pituitary tumors and the study of pituitary disease (acromegaly) .

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

P01241

Host

Mouse

Reactivity

Human

Immunogen

A full-length of human Growth Hormone protein was used as the immunogen for the Growth Hormone antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

GH/3155

Applications

IHC-P

Purity

Protein G affinity chromatography

Format

Purified

Buffer

0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Store the Growth Hormone antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This Growth Hormone antibody is available for research use only.

Storage Conditions

Store the Growth Hormone antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

Applications Notes

Optimal dilution of the Growth Hormone antibody should be determined by the researcher.

Location

Cytoplasmic

Image Legend

IHC testing of FFPE human pituitary with Growth Hormone antibody (clone GH/3155) . Required HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min.