NKX2.8 Antibody
The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects.
Product Specifications
UniProt
O15522
Host
Mouse
Immunogen
A recombinant human partial protein (amino acids 10-123) was used as the immunogen for the NKX2.8 antibody.
Clonality
Monoclonal
Isotype
IgG1 κ
Applications
WB
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the NKX2.8 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This NKX2.8 antibody is available for research use only.
CAS Number
9007-83-4
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