FCGRT Antibody / FcRn
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. FCGRT is present in the intestinal epithelium of neonates and mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn to acquire passive immunity. FCGRT is comprised of a heavy chain and -2-Microglobulin. FCGRT localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal degradation.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 2-4 µg/mL
UniProt
P55899
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 24-215) was used as the immunogen for the FCGRT antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
FCGRT/2932
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the FCGRT antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This FCGRT antibody is available for research use only.
Storage Conditions
Store the FCGRT antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the FCGRT antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
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