FCGRT Antibody / FcRn

This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. FCGRT is present in the intestinal epithelium of neonates and mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn to acquire passive immunity. FCGRT is comprised of a heavy chain and -2-Microglobulin. FCGRT localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal degradation.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 2-4 µg/mL

UniProt

P55899

Host

Mouse

Reactivity

Human

Immunogen

A recombinant human partial protein (amino acids 24-215) was used as the immunogen for the FCGRT antibody.

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

FCGRT/2932

Applications

IHC-P

Purity

Protein G affinity chromatography

Format

Purified

Buffer

0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Store the FCGRT antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This FCGRT antibody is available for research use only.

Storage Conditions

Store the FCGRT antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

Applications Notes

Optimal dilution of the FCGRT antibody should be determined by the researcher.

Location

Cytoplasmic

Image Legend

IHC staining of FFPE human testicular cancer with FCGRT antibody (clone FCGRT/2932) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.