CD64 Antibody / FCGR1A
Three different classes of IgG Fc receptors have been described: Fc stimulation. CD64 plays a putative role in the initiation of cell-mediated cytotoxicity. Thus far, three genes encoding four distinct CD64 transcripts have been described. CD64 has been shown to associate with signal transducing subunit of the high affinity IgE receptor. Src family kinases Hck and Lyn show increased kinase activity and will co-immunoprecipitate with CD64 subsequent to receptor cross linking.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells
UniProt
P12314
Host
Mouse
Reactivity
Human
Immunogen
Rheumatoid synovial fluid cells and human monocytes were used as the immunogen for the CD64 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
10.1
Applications
FACS
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the CD64 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD64 antibody is available for research use only.
Storage Conditions
Store the CD64 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CD64 antibody should be determined by the researcher.
Image Legend
Flow cytometry staining of monocyte-gated human PBM cells with CD64 antibody (clone 10.1) ; Gray=isotype control, Red= CD64 antibody.
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