Estrogen Receptor alpha Antibody
This monoclonal antibody is specific to estrogen receptor alpha (ER alpha) and shows minimal cross-reaction with other members of the family. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy. It strongly stains nuclei of epithelial cells in breast carcinomas.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P03372
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human full length protein was used as the immunogen for this Estrogen Receptor alpha antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
ESR1/1904
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Estrogen Receptor alpha antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Estrogen Receptor alpha antibody is available for research use only.
Storage Conditions
Store the Estrogen Receptor alpha antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Estrogen Receptor alpha antibody should be determined by the researcher.
Location
Nuclear
Image Legend
Western blot testing of human MCF7 cell lysate with Estrogen Receptor alpha antibody (clone ESR1/1904) . Predicted molecular weight ~66 kDa.
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