Cathepsin D Antibody
Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 52kDa preprocathepsin D that is cleaved and glycosylated to form a 48kDa procathepsin D and then further cleaved to produce 34kDa and 14kDa subunits (heavy and light chains, respectively) . Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 1-2 µg/mL
UniProt
P07339
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 104-250) was used as the immunogen of the Cathepsin D antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
CTSD/3276
Applications
IF, IHC-P, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the Cathepsin D antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Cathepsin D antibody is available for research use only.
Storage Conditions
Store the Cathepsin D antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the Cathepsin D antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Immunofluorescent staining of permeabilized human MCF7 cells with Cathepsin D antibody (clone CTSD/3276, green) and Reddot nuclear stain (red) .
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