ARK1C2 Antibody / Aldo-keto Reductase Family 1 Member C2

DDH2 / AKR1C2 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

P52895

Host

Mouse

Reactivity

Human

Immunogen

A recombinant human full-length AKR1C2 protein was used as the immunogen for the AKR1C2 antibody.

Clonality

Monoclonal

Isotype

IgG2a κ

Clone

CPTC-AKR1C2-1

Applications

WB, IHC-P

Purity

Protein G affinity chromatography

Format

Purified

Buffer

0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Store the AKR1C2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This AKR1C2 antibody is available for research use only.

Storage Conditions

Store the AKR1C2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

Applications Notes

Optimal dilution of the AKR1C2 antibody should be determined by the researcher.

Location

Cytoplasmic

Image Legend

IHC staining of FFPE human prostate carcinoma with AKR1C2 antibody (clone CPTC-AKR1C2-1) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.