CYP1A1/1A2 Antibody
Cytochrome P450 oxidase (commonly abbreviated CYP) is a generic term for a large number of related, but distinct, oxidative enzymes important in vertebrate physiology. The cytochrome P450 mixed-function monooxygenase system is probably the most important element of Phase I metabolism in mammals. P450s are membrane-bound, either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells where they metabolise thousands of endogenous and exogenous compounds. In the liver, these substrates include toxins, drugs, and other unneeded and potentially harmful molecules. Humans have 18 families of cytochrome P450 genes and 43 subfamilies; the CYP1 family is involved in drug metabolism and includes 3 subfamilies, 3 genes and 1 pseudogene.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1-2 µg/mL, Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P04798
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
3-methylcholanthrene induced rat cytochrome P450 protein was used as the immunogen for the CYP1A1/1A2 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
MC1
Applications
IF, WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the CYP1A1/1A2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CYP1A1/1A2 antibody is available for research use only.
Storage Conditions
Store the CYP1A1/1A2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CYP1A1/1A2 antibody should be determined by the researcher.
Image Legend
SDS-PAGE analysis of purified, BSA-free CYP1A1/1A2 antibody (clone MC1) as confirmation of integrity and purity.
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