BTLA Antibody / CD272
B and T lymphocyte attenuator (BTLA) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T-cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are coinhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T-cell activation by propagating inhibitory signals through BTLA. The BTLAHVEM interaction is conserved between Mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating)
UniProt
Q7Z6A9
Host
Mouse
Reactivity
Human
Immunogen
Recombinant extracellular human CD272/BTLA protein was used as the immunogen for this BTLA antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
BTLA/1528
Applications
ELISA
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the BTLA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This BTLA antibody is available for research use only.
Storage Conditions
Store the BTLA antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the BTLA antibody should be determined by the researcher.
Image Legend
SDS-PAGE analysis of purified, BSA-free BTLA antibody (clone BTLA/1528) as confirmation of integrity and purity.
Frequently Asked Questions
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