ZNF690 Antibody / ZSCAN29

Zinc finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc finger proteins contain a Kruppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger protein 690 (ZNF690), also known as ZSCAN29, is a 851 amino acid member of the Kruppel C2H2- type zinc finger protein family. Localized to the nucleus, ZNF690 contains six C2H2-type zinc fingers and one KRAB domain through which it is thought to be involved in DNA-binding and transcriptional regulation. Four isoforms of ZNF690 exist as a result of alternative splicing events.