BAFF Receptor Antibody / TNFRSF13C / CD268

Defects in TNFRSF13C/BAFF-R are the cause of immunodeficiency common variable type 4 (CVID4) ; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

Q96RJ3

Host

Mouse

Reactivity

Human

Immunogen

A recombinant full-length human protein was used as the immunogen for the BAFF Receptor antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

BAFFR/1557

Applications

IHC-P

Purity

Protein G affinity chromatography

Format

Purified

Buffer

1 mg/ml in 1X PBS; BSA free, sodium azide free

Reconstitution

Store the BAFF Receptor antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This BAFF Receptor antibody is available for research use only.

Storage Conditions

Store the BAFF Receptor antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Applications Notes

Optimal dilution of the BAFF Receptor antibody should be determined by the researcher.

Location

Cell surface

Image Legend

IHC staining of FFPE human tonsil with BAFF Receptor antibody (clone BAFFR/1557) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.