UPK1A Antibody / Uroplakin 1A
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
O00322
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 114-173 were used as the immunogen for the UPK1A antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
UPK1A/2921
Applications
ELISA, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the UPK1A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This UPK1A antibody is available for research use only.
Storage Conditions
Store the UPK1A antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the UPK1A antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
Image Legend
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