Cadherin 17 Antibody
It recognizes a glycosylated protein of 120kDa, which is identified as Cadherin 17 (also known as LI Cadherin) . The cadherins are a family of Calcium-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. LI-cadherin (for liver-intestine-cadherin) expression is restricted to liver and intestine tissues and is specifically localized to the basolateral domain of hepatocytes and enterocytes.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/10^6 cells, Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 2-4 µg/mL
UniProt
Q12864
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 242-418) was used as the immunogen for the Cadherin 17 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
CDH17/2618
Applications
FACS, IHC-P, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Cadherin 17 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Cadherin 17 antibody is available for research use only.
Storage Conditions
Store the Cadherin 17 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Cadherin 17 antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
Image Legend
Flow cytometry testing of human MCF7 cells with Cadherin 17 antibody (clone CDH17/2618) ; Red=isotype control, Blue= Cadherin 17 antibody.
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