NPM Antibody / Nucleophosmin
The protein encoded by the NPM1 gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. [RefSeq]
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT, Prediluted IHC only format: incubate for 30 min at RT (1)
UniProt
P06748
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 185-287 from the human protein was used as the immunogen for the NPM antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
NLPP1-1
Applications
IHC-P, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the NPM antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This NPM antibody is available for research use only.
Storage Conditions
Store the NPM antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Nuclear, cytoplasmic
Image Legend
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