TIGIT Antibody / VSTM3 / VSIG9
TIGIT is a checkpoint inhibitor which binds with high affinity to the poliovirus receptor (PVR), causing increased IL10 secretion, decreased IL12B secretion. TIGIT binding to PVR also causes the suppression of T cell activation by promoting the generation of mature immuno-regulatory dendritic cells. It is expressed at low levels on natural killer (NK) cells, as well as peripheral memory and regulatory CD4+ T cells. At the protein level, it is upregulated following the activation of these cells. Functionally, TIGIT is similar to CTLA4. The ligands for TIGIT include CD155 (signal abrogation) and CD226 (signal stimulation). It has been demonstrated to be upregulated on T cells in many cancers and is an immuno-oncology target for therapy.
Product Specifications
UniProt
Q495A1
Host
Mouse
Immunogen
A recombinant human TIGIT protein fragment within amino acids 22-141 was used as the immunogen for the TIGIT antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Applications
ELISA, FACS, IHC-P
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the TIGIT antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This TIGIT antibody is available for research use only.
CAS Number
9007-83-4
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