PAPPA Antibody / Pappalysin-1
The PAPPA gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs) . Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [RefSeq]
Product Specifications
CAS Number
9007-83-4
Specifications
UniProt
Q13219
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 351-523 from the human protein was used as the immunogen for the PAPPA antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
IDIP-1
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the PAPPA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PAPPA antibody is available for research use only.
Storage Conditions
Store the PAPPA antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic
Image Legend
Frequently Asked Questions
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