ELQ-598
ELQ-598, as a prodrug, is converted into the active drug ELQ-596 upon oral administration. ELQ-598 demonstrates potent parasitic growth inhibition capabilities (IC50= 37 nM) . ELQ-598 also shows low toxicity towards human cells (IC50= 19 μM) . ELQ-598 can be used for research into babesiosis[1].
Product Specifications
CAS Number
[3023709-99-8]
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/elq-598.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC2=C(N=C(C)C(C3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C3)=C2OCOC(OCC)=O)C=C1OC
Molecular Formula
C28H23ClF3NO6
Molecular Weight
561.93
References & Citations
[1]Vydyam P, et al. Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis. ACS Infect Dis. 2024 Apr 12;10 (4) :1405-1413.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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