Recombinant Bcl10 Antibody
Bcl10, with an N-terminal caspase recruitment domain (CARD), is found in a number of apoptotic regulatory molecules. It was identified through its direct involvement in t (1;14) of mucosa-associated lymphoid tissue (MALT) lymphoma. Expression of Bcl10 was shown to induce NFkB activation in a NIK-dependent pathway. This antibody labels subpopulations of normal B and T cells and is a useful tool for the sub-classification of lymphomas. In MALT lymphomas with the t (1;14) translocation, while 55% of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.
Product Specifications
CAS Number
9000-83-3
Specifications
Flow cytometry: 1-2ug/10^6 cells, Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 122-168 from the human protein was used as the immunogen for this recombinant Bcl10 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
BL10/2988R
Type
Recombinant
Applications
FACS, IF, IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the recombinant Bcl10 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant Bcl10 antibody is available for research use only.
Storage Conditions
Store the recombinant Bcl10 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Nuclear and cytoplasmic
Image Legend
Immunofluorescent staining of PFA-fixed human K562 cells with recombinant Bcl10 antibody (clone BL10/2988R, green) and phalloidin (red) .
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