MMP3 Antibody
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB) . MMP catalysis requires both calcium and zinc. MMP3, MMP10 and MMP11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP3 activation of procollagenase can occur via two pathways. Direct activation by MMP3 is slow and activation by MMP3 in conjunction with tissue or plasma proteinases is rapid. MMP10 is expressed in small intestine, and at lower levels in lung and heart. MMP11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA (order BSA/sodium azide-free format for coating), Western blot: 1-2 µg/mL
UniProt
P08254
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 236-363 was used as the immunogen for the MMP3 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
MMP3/2655
Applications
ELISA, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the MMP3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This MMP3 antibody is available for research use only.
Storage Conditions
Store the MMP3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic, secreted
Image Legend
Western blot testing of human Raji, HEK293, and HT-29 cell lysate with MMP3 antibody. Predicted molecular weight ~54 kDa.
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