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Calretinin Antibody / CALB2 / Calbindin 2

This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. Calretinin/Calbindin 2 plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [RefSeq]

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT, Prediluted IHC only format: incubate for 30 min at RT (1)

UniProt

P22676

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 23-242 from the human protein was used as the immunogen for the Calretinin antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

CLRT-1

Applications

IHC-P

Purity

Protein G affinity

Format

Purified

Buffer

1 mg/ml in 1X PBS; BSA free, sodium azide free

Reconstitution

Store the Calretinin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This Calretinin antibody is available for research use only.

Storage Conditions

Store the Calretinin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Location

Nuclear, cytoplasmic

Image Legend

IHC testing of FFPE human cerebellum with Calretinin antibody (clone CLRT-1) . HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.

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