Prealbumin Antibody / Transthyretin / TTR
Prealbumin, also designated transthyretin, is a major thyroid-hormone binding protein involved in transporting thyroxine from the bloodstream to the brain. Prealbumin is located in the cytoplasm and in the vesicles of developing rat brain cells, and is thought to be transported there from the cerebrospinal fluid via endocytosis. Sequence variants of this protein have been identified in amyloid fibrils from patients with familial amyloidotic polyneuropathy (FAP), the most common form of hereditary systemic amyloidosis. Although the biologically active form of Prealbumin is a tetramer, the amyloidogenic intermediate is thought to be a monomeric species. Prealbumin also binds to the retinol carrier protein RBP (retinol-binding protein) .
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA: order BSA/sodium azide-free format for coating, Western blot: 1-2 µg/mL
UniProt
P02766
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for this Prealbumin antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
CPTC-TTR-1
Applications
ELISA, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Prealbumin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Prealbumin antibody is available for research use only.
Storage Conditions
Store the Prealbumin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Prealbumin antibody should be determined by the researcher.
Location
Cytoplasmic, secreted
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