TMEPAI Antibody / PMEPA1

PMEPA1 (prostate transmembrane protein, androgen induced 1), or TMEPAI (Transmembrane prostate androgen induced protein) is a 287 amino acid single-pass membrane protein that contains WW-binding motifs and localizes to the cell membrane. Expressed at high levels in prostate, kidney and ovary, PMEPA1/TMEPAI interacts with NEDD4 and may play a role in regulating AR (androgen receptor) levels, specifically in prostate cells. Down regulation of TMEPAI is observed in prostate tumors, suggesting that TMEPAI may exhibit activity as a tumor suppressor. Overexpression of this protein may play a role in multiple types of cancer.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT (1)

UniProt

Q969W9

Host

Mouse

Reactivity

Human

Immunogen

Full-length recombinant human protein was used as the immunogen for the TMEPAI antibody.

Clonality

Monoclonal

Isotype

IgG

Clone

PMEPA1/2697

Applications

IHC-P

Purity

Protein G affinity chromatography

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Reconstitution

Store the TMEPAI antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This TMEPAI antibody is available for research use only.

Storage Conditions

Store the TMEPAI antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

Location

Cell surface, cytoplasm

Image Legend

IHC staining of FFPE human prostate carcinoma with TMEPAI antibody (clone PMEPA1/2697) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.