RAD51 Antibody
RAD51 is one of the key factors of DNA repair by homologous recombination and has been shown to have anti-apoptotic activity in tumor cells. RAD51 protein interacts with a variety of tumor suppressor proteins including p53, BRCA1 and BRCA2. Elevated expression of RAD51 enhances radio-resistance of human tumor cells. Overexpression of RAD51 protein in tumor cells renders them resistant against cytotoxic drugs like Cisplatin. RAD51 interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of RAD51. High-level expression of RAD51 has been observed in a variety of human malignancies. RAD51 overexpression correlates with histological grading of the tumor in invasive ductal mammary carcinoma.
Product Specifications
UniProt
Q06609
Host
Mouse
Immunogen
A portion of amino acids 1-134 from the human protein was used as the immunogen for this RAD51 antibody.
Clonality
Monoclonal
Isotype
IgG
Applications
ELISA, WB
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the RAD51 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This RAD51 antibody is available for research use only.
CAS Number
9007-83-4
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