9-Aminoacridine

9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic) . 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections[1][2][3].

Product Specifications

CAS Number

[90-45-9]

Product Name Alternative

Aminacrine

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335, H410

Target

Bacterial; HIV

Type

Dye Reagents

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/9-Aminoacridine.html

Purity

99.36

Solubility

DMSO : 27.5 mg/mL (ultrasonic)

Smiles

NC1=C(C=CC=C2)C2=NC3=CC=CC=C31

Molecular Formula

C13H10N2

Molecular Weight

194.24

Precautions

H302, H315, H319, H335, H410

References & Citations

[1]S Grzesiek, et al. The 'delta pH'-probe 9-aminoacridine: response time, binding behaviour and dimerization at the membrane. Biochim Biophys Acta. 1988 Mar 3;938 (3) :411-24.|[2]Pengfei She, et al. Repurposing 9-Aminoacridine as an Adjuvant Enhances the Antimicrobial Effects of Rifampin against Multidrug-Resistant Klebsiella pneumonia. Microbiol Spectr. 2023 Jun 15;11 (3) :e0447422.|[3]Irene Guendel, et al. 9-Aminoacridine inhibition of HIV-1 Tat dependent transcription. Virol J. 2009 Jul 24:6:114.