Recombinant AURKB Antibody / Aurora B
Recognizes a protein of 39kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
Product Specifications
CAS Number
9000-83-3
Specifications
UniProt
Q96GD4
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 89-251 was used as the immunogen for this recombinant AURKB antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
ARRK2-2R
Type
Recombinant
Applications
IHC-P
Purity
Protein A affinity
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the recombinant AURKB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant AURKB antibody is available for research use only.
Storage Conditions
Store the recombinant AURKB antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Applications Notes
Optimal dilution of the recombinant AURKB antibody should be determined by the researcher.
Location
Nuclear, cytoplasmic
Image Legend
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
SpUlp1 (S. pombe Ubiquitin-like Protein 1, SpUlp 1, SpUlp-1) (PE)
SpUlp1 (S. pombe Ubiquitin-like Protein 1, SpUlp 1, SpUlp-1) (PE)
