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Neuregulin-1 Antibody / NRG1

Heregulin-1 / Neuregulin-1 is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD) .

Product Specifications

CAS Number

9007-83-4

Specifications

ELISA (order BSA/sodium azide-free format for coating), Immunofluorescence: 1-2 µg/mL

UniProt

Q02297

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 21-242 from the human protein was used as the immunogen for this Neuregulin-1 antibody.

Clonality

Monoclonal

Isotype

IgG

Clone

NRG1/2752

Applications

ELISA, IF

Purity

Protein G affinity chromatography

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Reconstitution

Store the Neuregulin-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This Neuregulin-1 antibody is available for research use only.

Storage Conditions

Store the Neuregulin-1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

Location

Cytoplasmic, plasma membrane, nuclear

Image Legend

Immunofluorescent staining of human MCF7 cells with Neuregulin-1 antibody (clone NRG1/2752, green) and Reddot nuclear stain (red) .

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