Ferritin Antibody (light chain specific)
Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains, ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III) . Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 38-165 of human FTL were used as the immunogen for this Ferritin antibody (light chain specific) .
Clonality
Monoclonal
Isotype
IgG2b
Clone
FTLC1-1
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Ferritin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Ferritin antibody is available for research use only.
Storage Conditions
Store the Ferritin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Location
Cytoplasmic
Image Legend
Western blot testing of human HeLa cell lysate with Ferritin antibody (clone FTLC1-1) . Predicted molecular weight: ~20 kDa.
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