Ku70 + Ku80 Antibody PE Conjugate
Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V (D) J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system. In addition to its role in NHEJ, Ku is also required for telomere length maintenance and subtelomeric gene silencing. Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein. [Wiki]
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 5ul/test/10e6 cells in 100ul or 5ul/100ul whole blood
Host
Mouse
Reactivity
Human
Immunogen
A human cell nuclear fraction was used as the immunogen for this Ku70 + Ku80 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
LKAP1-1
Applications
FACS
Purity
Protein G purified
Format
PE Conjugate
Buffer
1X PBS, pH 7.4
Reconstitution
Store the Ku70 + Ku80 antibody at 2-8°C. Conjugate is light sensitive, store in the dark.
Limitations
This Ku70 + Ku80 antibody is available for research use only.
Storage Conditions
Store the Ku70 + Ku80 antibody at 2-8°C. Conjugate is light sensitive, store in the dark.
Formulation
500 ul at 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Titering of the Ku70 + Ku80 antibody may be required for optimal performance.
Location
Nuclear
Image Legend
Intracellular FACS testing of K562 cells with PE conjugated Ku70 + Ku80 antibody (red) and isotype control (green) .
Documents
Frequently Asked Questions
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