CD74 Antibody
CD74 associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta) . Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [RefSeq]
Product Specifications
CAS Number
9007-83-4
Specifications
UniProt
P04233
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the CD74 antibody. The epitope is known to be extracellular.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CDLA74-1
Applications
FACS, IF, IHC
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the CD74 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD74 antibody is available for research use only.
Storage Conditions
Store the CD74 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cell surface and paranuclear globular
Image Legend
Flow cytometry testing of human Raji cells with CD74 antibody (clone CDLA74-1) ; Red=isotype control, Blue= CD74 antibody.
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