CAD Antibody / CALD1 / Caldesmon (HMW)
Caldesmon is an actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments) . Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity) . [UniProt]
Product Specifications
CAS Number
9007-83-4
Specifications
UniProt
Q05682
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the CAD antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CDSM-3
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the CAD antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CAD antibody is available for research use only.
Storage Conditions
Store the CAD antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic
Image Legend
IHC testing of FFPE human uterus with CAD antibody (clone CDSM-3) .
Documents
Frequently Asked Questions
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