CELA3B Antibody
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six genes which encode the structurally similar proteins: Elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, 3B has little elastolytic activity. Like most of the human elastases, 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein; it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. It may also function in the intestinal transport and metabolism of cholesterol. Elastases 3A/B have been referred to as Protease E and as Elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL
UniProt
P08861
Host
Mouse
Reactivity
Human
Immunogen
A partial recombinant protein (aa 82-238) was used as the immunogen for the CELA3B antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
ELTS3B-1
Applications
WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the CELA3B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CELA3B antibody is available for research use only.
Storage Conditions
Store the CELA3B antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CELA3B antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Frequently Asked Questions
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