CD10 Antibody / Neprilysin
CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA) and Neprilysin, is a cell surface enzyme with neutral metalloendopeptidase activity, which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, and on cells from patients with chronic myelocytic leukemia (CML) . It is also expressed on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA: 2-4 µg/mL (order BSA/azide-free format), Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P08473
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 297-483 from the human protein was used as the immunogen for the CD10 antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Clone
MME/1892
Applications
ELISA, WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the CD10 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD10 antibody is available for research use only.
Storage Conditions
Store the CD10 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CD10 antibody should be determined by the researcher.
Location
Cell surface, Cytoplasmic
Image Legend
Western blot testing of human 1) Raji and 2) Ramos cell lysate with CD10 antibody (clone MME/1892) . Routinely visualized at ~100 kDa.
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