PU.1 Antibody / SPI1
PU.1 is a member of the ETS family of transcription factors and is important for normal B-cell development. It is expressed in the myeloid lineage and in immature as well as mature B-lymphocytes, with the exception of plasma cells. PU.1 is expressed in germinal center B-cells and mantle B-cells. Various lymphomas are also positive for this marker. It is essential during early B-cell differentiation. The absence of PU.1 results in total block of B-cell development at the pre-pro stage. PU.1 plays a key role in normal myeloid differentiation, and regulates the expression of immunoglobulin and other genes that are important for B-cell development.
Product Specifications
UniProt
P17947
Host
Mouse
Immunogen
A portion of amino acids 16-170 from the human protein was used as the immunogen for the PU.1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Applications
FACS, IF, WB, IHC-P
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the PU.1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PU.1 antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6698799/datasheet/v3875-100ug.pdf
CAS Number
9007-83-4
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