BCMA Antibody / CD269 / TNFRSF17
The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells) . Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE) .
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA: order BSA/sodium azide-free format for coating, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q02223
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 78-184 from the human protein was used as the immunogen for the BCMA antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Clone
BCMA/2366
Applications
ELISA, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Limitations
This BCMA antibody is available for research use only.
Storage Conditions
Store the BCMA antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Titering of the BCMA antibody may be required for optimal performance.
Location
Cell surface
Image Legend
Documents
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