CD79b Antibody

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. [UniProt]

Product Specifications

CAS Number

9007-83-4

Specifications

IHC (FFPE) : 1-2 µg/mL for 30 min at RT

UniProt

P40259

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 29-159 was used as the immunogen for the CD79b antibody.

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

CDLA79b-1

Applications

IHC-P

Purity

Protein G affinity chromatography

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Reconstitution

Store the CD79b antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This CD79b antibody is available for research use only.

Storage Conditions

Store the CD79b antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

Applications Notes

The stated application concentrations are suggested starting points. Titration of the CD79b antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Location

Cell surface

Image Legend

IHC testing of FFPE human tonsil tissue with CD79b antibody (clone CDLA79b-1) . HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.