AIF1 Antibody / IBA1
AIF1 (Allograft inflammatory factor 1), also called IBA1 (Ionized calcium-binding adapter molecule 1) is a cytoplasmic, calcium-binding protein that is thought to play a role in macrophage activation and function. AIF1/IBA1, containing two EF domains, is induced by cytokines and Interferons. In an unstimulated state, it colocalizes with actin, and upon stimulation, translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding the protein resides in the tumor necrosis factor (TNF) cluster of genes, located in the region represented by the human major histocompatibility complex (MHC) .
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P55008
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 1-146 from the human protein was used as the immunogen for the AIF1 antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Clone
AIF1/2493
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the AIF1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This AIF1 antibody is available for research use only.
Storage Conditions
Store the AIF1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Titering of the AIF1 antibody may be required for optimal performance.
Location
Cytoplasmic, membranous
Image Legend
Documents
Frequently Asked Questions
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