CD79b Antibody

CD79 (also designated Ig alpha/Ig beta) is a heterodimer composed of alpha chains, designated CD79A or MB-1, and beta chains, designated CD79B or B29. The B cell antigen receptor complex (BCR) is formed by the association of CD79 with a membrane immunoglobulin, such as IgM or IgD. The membrane immunoglobulins IgM and IgD achieve surface expression and antigen presentation function in response to CD79 association. The cytoplasmic tails of both CD79A and CD79B contain an ITAM (immuno-receptor tyrosine-based activation) motif, which acts to initiate the BCR signaling reactions by binding to and activating tyrosine kinases.

Product Specifications

CAS Number

9007-83-4

Specifications

ELISA: 2-4 µg/mL (order BSA/azide-free format), Western blot: 1-2 µg/mL

UniProt

P40259

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 29-159 was used as the immunogen for the CD79b antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

IGB/1843

Applications

ELISA, WB

Purity

Protein G affinity chromatography

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Reconstitution

Store the CD79b antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This CD79b antibody is available for research use only.

Storage Conditions

Store the CD79b antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

Applications Notes

Optimal dilution of the CD79b antibody should be determined by the researcher.

Location

Cell surface

Image Legend

Western blot testing of 1) partial recombinant protein and 2) human Raji cell lysate with CD79b antibody (clone IGB/1843) . Expected molecular weight: 26-39 kDa depending on glycosylation level.