3- (4-Hydroxy-1-oxoisoindolin-2-yl) piperidine-2,6-dione
Selected Variant
HY-W076696-01
Size: 250 mg
Lenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-OH can be connected to the ligand for protein by a linker to form PROTAC.
Product Specifications
CAS Number
1061604-41-8
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lenalidomide-4-oh.html
Purity
99.62
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C(N(CC1=C2C=CC=C1O)C2=O)CC3)NC3=O
Molecular Formula
C13H12N2O4
Molecular Weight
260.25
Precautions
H302, H312, H315, H319
References & Citations
[1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Price
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