3-(4-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Product Specifications
UNSPSC Description
Lenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-OH can be connected to the ligand for protein by a linker to form PROTAC.
Target Antigen
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lenalidomide-4-oh.html
Purity
99.62
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C(N(CC1=C2C=CC=C1O)C2=O)CC3)NC3=O
Molecular Weight
260.249
References & Citations
[1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W076696/Lenalidomide-4-OH-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W076696/Lenalidomide-4-OH-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1061604-41-8
Available Sizes
Curated Selection
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