Topoisomerase II alpha Antibody / TOP2A
This mAb recognizes an ~170kDa protein which is identified as Topoisomerase IIa, and shows no cross-reaction with Topoisomerase IIb or I. Topo IIa plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topo IIa is also implicated in drug resistance of tumor cells.
Product Specifications
UniProt
P11388
Host
Mouse
Immunogen
Amino acids 1352-1493 from the human protein were used as the immunogen for this Topoisomerase II alpha antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Applications
IF, WB, IHC-P
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Topoisomerase II alpha antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Topoisomerase II alpha antibody is available for research use only.
CAS Number
9007-83-4
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