P-Cadherin Antibody / CDH3
Recognizes a protein of 116kDa, identified as P-Cadherin, or Cadherin 3 or CDH3. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congenital hypotrichosis with juvenile macular dystrophy.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 0.5-1ug/10^6 cells, Immunofluorescence: 1-2 µg/mL, Western blot: 0.5-1 µg/mL
UniProt
P22223
Host
Mouse
Reactivity
Human
Immunogen
Membrane from trypsinized A431 cells was used as the immunogen for this P-Cadherin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
6A9
Applications
FACS, IF, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the P-Cadherin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This P-Cadherin antibody is available for research use only.
Storage Conditions
Store the P-Cadherin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Location
Cell surface, cytoplasmic
Image Legend
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